Protein Details: Two-pore potassium channel 3

Protein ID

ICDB_Pro_1639

Protein Name

Two-pore potassium channel 3

Gene Name

TPK3; KCO6; At4g18160; F15J5.130

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

436 amino acids

AlphaFoldDB

AF-Q9SVV6-F1-model_v4.pdb

Function

Two-pore potassium channel modulating the proton motive force (pmf) necessary to convert photochemical energy into physiological functions. Mediates the potassium efflux from the thylakoid lumen required for the regulation of the transmembrane electrical potential, the enhancement of the pH gradient for ATP synthesis, the regulation of electron flow, and pH-mediated photoprotective responses. Requires calcium for channel activity.

Sequence

MANEGSDPLLQYMISPRLKKPPQLLFPLPEDNEVAIPMPMTPSEFKERLIFGPFSCSPRDSSHFIDSMKQPSPSSSSTAVNNPFSDSSTLDPLLPPPPPQPEPWLSDQTSSHCQGHALHRSKTAPAMAVINDLHHPIRQKDPTETSRSVVRQAFALLVVYLSLGVLIYWLNRDHYVVNQTHPVVDGLYFCIVTMCTIGYGDITPNSVVTKLFSIMFVLVGFGFIDILLSGMVSYVLDLQESYMLDSAKRRDEPEKRRSYIIDVKKGRMRIRLKVALALGVVVLCIAVGVGIMHFIEEIGWLDSFYLSVMSVTTVGYGDRAFKTLPGRLFAAIWLLVSTLAVARAFLYLAEARVDKRNRERAKKVLCETMSVSQFFAADIDNNGCVSKAEYVIYKLKEMEKITDKDILPISKQFDKLDRCSNGKITLLDLLEGGSGD

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

378;380;382;384;389;417;421;423;428

Disease

Location

Expressed in roots; cotyledons; stems; hypocotyls; leaves and flowers. Detected in root tips and in mesophyll cells and guard cells of the leaves

DOI ID

10.1104/pp.126.4.1646; 10.1073/pnas.0401502101; 10.1111/j.1365-313x.2007.03255.x; 10.1093/mp/ssn064; 10.1126/science.1242113

RefSeq

NP_193550.1